Regenerative Medicine Laboratory in the Department of Clinical Sciences, Cummings School of Veterinary Medicine

To increase knowledge about the biology of stem cells, and to translate this information into safer, more efficacious stem cell based therapies for animals and humans

In the lab

  • Normal sheep airway stained for basal cells:  cytokerin 5 (green) and p63 (red); nuclear stain is blue.
  • Normal sheep lung:  stained for collagen IV (green) and elastin (red).
  • Equine umbilical cord (Wharton’s Jelly) derived mesenchymal stem cells shown as outgrowth from explanted tissue.
  • Each of these bronchospheres (circular collection of cells with lumen) was grown from a single human basal cell in our laboratory.
  • Human basal cell derived bronchosphere, immunostained for cytokeratin 5 (green) and p63 (red/pink); blue is nuclear stain.
  • Lung derived mesenchymal stem cells are highly clonogenic (shown on left column) compared to committed lung fibroblasts (shown in right column).   The therapeutic potential of autologous LMSCs is a focus of Dr. Andrew Hoffman’s research at the RML.
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