Global gene expression patterns in the post-pneumonectomy lung of adult mice.

Paxson J, Parkin C, Iyer L, Mazan MR, Ingenito EP, and Hoffman AM (2009).   Global gene expression patterns during post-pneumonectomy lung regeneration in adult mice.   Resp Research 10:92; PMID 19804646.


Adult mice have a remarkable capacity to regenerate functional alveoli following either lung resection or injury that exceeds the regenerative capacity observed in larger adult mammals. The molecular basis for this unique capability in mice is largely unknown. We examined the transcriptomic responses to single lung pneumonectomy in adult mice in order to elucidate prospective molecular signaling mechanisms used in this species during lung regeneration.

Read more at PubMed: http://www.ncbi.nlm.nih.gov/pubmed/19804646

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