Matrix modulation of compensatory lung regrowth and progenitor cell proliferation in mice.

Hoffman AM, Shifren A, Mazan MR, Gruntman AM, Lascola K, Nolen-Walston R, Kim CF, Tsai L, Pierce RA, Mecham R, and Ingenito EP (2010).  Matrix modulation of compensatory lung regrowth and progenitor cell proliferation in mice   Am J Physiol: Lung Cell Mol Physiol  298:L158-68; PMID 19915155.


Mechanical stress is an important modulator of lung morphogenesis, postnatal lung development, and compensatory lung regrowth. The effect of mechanical stress on stem or progenitor cells is unclear. We examined whether proliferative responses of epithelial progenitor cells, including dually immunoreactive (CCSP and proSP-C) progenitor cells (CCSP+/SP-C+) and type II alveolar epithelial cells (ATII), are affected by physical factors found in the lung of emphysematics, including loss of elastic recoil, reduced elastin content, and alveolar destruction.

Read more at PubMed: http://www.ncbi.nlm.nih.gov/pubmed/19915155

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