Design and testing of biological scaffolds for delivering reparative cells to target sites in the lung.

Ingenito EP, Sen E, Tsai L, Murthy S, Hoffman AM (2010).  Design and testing of biological scaffolds for delivery reparative cells to target sites in the lung.  J Tiss Eng Reg Med   4:259-272; PMID: 20020503.


This study summarizes the development and testing of a scaffold to promote engraftment of cells in the distal lung. A fibrinogen-fibronectin-vitronectin hydrogel (FFVH) was developed and optimized with respect to its mechanical and biological properties for this application. In vitro, FFVH scaffolds promoted attachment, histiotypic growth and expression of basement membrane proteins by primary ovine lung mesenchymal cells derived from lung biopsies.

Read more at PubMed: http://www.ncbi.nlm.nih.gov/pubmed/20020503

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