Lung-derived mesenchymal stromal cell post-transplantation survival, persistence, paracrine expression, and repair of elastase-injured lung.

Hoffman AM, Paxson J, Mazan M, Davis A, Tyagi S, Murthy S, and Ingenito EP (2011).  Lung mesenchymal stromal cell post-transplantation survival, persistence, paracrine expression, and repair of elastase injured lung.  Stem Cells Develop, DOI: 10.1089/scd.2011.0105; PMID 21585237.


While multipotent mesenchymal stromal cells have been recently isolated from adult lung (L-MSCs), there is very limited data on their biological properties and therapeutic potential in vivo. How L-MSCs compare with bone marrow-derived MSCs (BM-MSCs) is also unclear. In this study, we characterized L-MSC phenotype, clonogenicity, and differentiation potential, and compared L-MSCs to BM-MSCs in vivo survival, retention, paracrine gene expression, and repair or elastase injury after transplantation.

Read more at PubMed: http://www.ncbi.nlm.nih.gov/pubmed/21585237

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