Age-dependent decline in mouse lung regeneration with loss of lung fibroblast clonogenicity and increased myofibroblastic differentiation.

Paxson J, Gruntman A, Parkin C, Mazan M, Davis A, Ingenito E, and Hoffman AM (2011).  Age dependent decline in lung regeneration with loss of clonogenicity and myofibroblast differentiation of lung fibroblasts.  PlosOne, published 30 Aug 2011 10.1371/journal.pone.0023232; PMID 21912590.

While aging leads to a reduction in the capacity for regeneration after pneumonectomy (PNX) in most mammals, this biological phenomenon has not been characterized over the lifetime of mice. We measured the age-specific (3, 9, 24 month) effects of PNX on physiology, morphometry, cell proliferation and apoptosis, global gene expression, and lung fibroblast phenotype and clonogenicity in female C57BL6 mice.

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