Endogenous distal airway progenitor cells, lung mechanics, and disproportionate lobar growth following long-term postpneumonectomy in mice.

Eisenhauer P, Earle B, Loi R, Sueblinvong V, Goodwin M, Allen G, Lundblad L, Mazan M, Hoffman AM,  Weiss DJ.  Endogenous Distal Airway Progenitor Cells, Lung Mechanics, and Disproportionate Lobar Growth following Long-Term Post-Pneumonectomy in Mice.  Stem Cells, 2013, 1;188(3):370-5; PMID: 23533195


Using a model of postpneumonectomy (PNY) compensatory lung growth in mice, we previously observed an increase in numbers of a putative endogenous distal airway progenitor cell population (CCSP(pos) /pro-SPC(pos) cells located at bronchoalveolar duct junctions [BADJs]), at 3, 7, and 14 days after pneumonectomy, returning to baseline at 28 days post-PNY. As the origin of these cells is poorly understood, we evaluated whether bone marrow cells contributed to the pool of these or other cells during prolonged post-PNY lung regrowth.

Read more at PubMed: http://www.ncbi.nlm.nih.gov/pubmed/23533195

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