Age Dependence of Lung Mesenchymal Stromal Cell Dynamics Following Pneumonectomy

Paxson J, Gruntman AM, Davis AM, Parkin CM, Ingenito EP, and Hoffman AM.  Age Dependence of Lung Mesenchymal Stromal Cell Dynamics Following Pneumonectomy,  Stem Cells Develop, 2013, 22(24):3214-25, PMID 23895415.


Aging is a critical determinant of regenerative capacity in many organ systems, but it remains unresolved in the lung. This study examines murine lung cell dynamics during age-dependent lung regeneration. Proliferation of lung progenitor cells (EpCAM(neg)/Sca-1(high) lung mesenchymal stromal cells – LMSCs, EpCAM(pos)/Sca-1(low) epithelial progenitor cells, proSP-C(pos) alveolar type II epithelial cells – AECII, and CD31(pos) – endothelial cells) was tracked to day 3 or 7 after pneumonectomy (PNX) or SHAM surgery in 3, 9, and 17 month mice.

Read more at PubMed: http://www.ncbi.nlm.nih.gov/pubmed/23895415

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