Paxson J, Gruntman AM, Davis AM, Parkin CM, Ingenito EP, and Hoffman AM. Age Dependence of Lung Mesenchymal Stromal Cell Dynamics Following Pneumonectomy, Stem Cells Develop, 2013, 22(24):3214-25, PMID 23895415.
Aging is a critical determinant of regenerative capacity in many organ systems, but it remains unresolved in the lung. This study examines murine lung cell dynamics during age-dependent lung regeneration. Proliferation of lung progenitor cells (EpCAM(neg)/Sca-1(high) lung mesenchymal stromal cells – LMSCs, EpCAM(pos)/Sca-1(low) epithelial progenitor cells, proSP-C(pos) alveolar type II epithelial cells – AECII, and CD31(pos) – endothelial cells) was tracked to day 3 or 7 after pneumonectomy (PNX) or SHAM surgery in 3, 9, and 17 month mice.
Read more at PubMed: http://www.ncbi.nlm.nih.gov/pubmed/23895415