Publications

Regenerative cells in the ageing lung

Hoffman AM. Regenerative cells in the ageing lung. In: Springer International Publishing Switzerland 2015, I. Bertoncello (Ed.), Stem Cells in the Lung, Stem Cell Biology and Regenerative. Medicine, DOI 10.1007/978-3-319-21082-7_8

Systemic Administration of Human Bone Marrow-Derived Mesenchymal Stromal Cell Extracellular Vesicles Ameliorates Aspergillus Hyphal Extract-Induced Allergic Airway Inflammation in Immunocompetent Mice.

Stem Cells Transl Med. 2015 Sep 16. pii: sctm.2014-0280. [Epub ahead of print]
Systemic Administration of Human Bone Marrow-Derived Mesenchymal Stromal Cell Extracellular Vesicles Ameliorates Aspergillus Hyphal Extract-Induced Allergic Airway Inflammation in Immunocompetent Mice.
Cruz FF1, Borg ZD1, Goodwin M1, Sokocevic D1, Wagner DE1, Coffey A1, Antunes M1, Robinson KL1, Mitsialis SA1, Kourembanas S1, Thane K1, Hoffman AM1,McKenna DH1, Rocco PR1, Weiss DJ2.

Equine model for soft-tissue regeneration.

J Biomed Mater Res B Appl Biomater. 2015 Aug;103(6):1217-27. doi: 10.1002/jbm.b.33299. Epub 2014 Oct 28.
Equine model for soft-tissue regeneration.
Bellas E1, Rollins A2, Moreau JE1, Lo T3, Quinn KP1, Fourligas N1, Georgakoudi I1, Leisk GG3, Mazan M2, Thane KE2, Taeymans O2, Hoffman AM2, Kaplan DL1,Kirker-Head CA2.

Relationships between equine airway reactivity measured by flowmetric plethysmography and specific indicators of airway inflammation in horses with suspected inflammatory airway disease.

Equine Vet J. 2015 Jul 14. doi: 10.1111/evj.12482. [Epub ahead of print]
Relationships between equine airway reactivity measured by flowmetric plethysmography and specific indicators of airway inflammation in horses with suspected inflammatory airway disease.
Wichtel M1, Gomez D2, Burton S3, Wichtel J1, Hoffman A4.

Lung regeneration and translational implications of the postpneumonectomy model.

Thane K, Ingenito EP, and Hoffman AM. Invited Review: Lung regeneration and translational implications of the post-pneumonectomy model. Translational Research. 2014 Apr:163(4):363-76.

Lung regeneration research is yielding data with increasing translational value. The classical models of lung development, postnatal alveolarization, and postpneumonectomy alveolarization have contributed to a broader understanding of the cellular participants including stem-progenitor cells, cell-cell signaling pathways, and the roles of mechanical deformation and other physiologic factors that have the potential to be modulated in human and animal patients.
Read more at PubMed: http://www.ncbi.nlm.nih.gov/pubmed/24316173

Age Dependence of Lung Mesenchymal Stromal Cell Dynamics Following Pneumonectomy

Paxson J, Gruntman AM, Davis AM, Parkin CM, Ingenito EP, and Hoffman AM.  Age Dependence of Lung Mesenchymal Stromal Cell Dynamics Following Pneumonectomy,  Stem Cells Develop, 2013, 22(24):3214-25, PMID 23895415.

Aging is a critical determinant of regenerative capacity in many organ systems, but it remains unresolved in the lung. This study examines murine lung cell dynamics during age-dependent lung regeneration. Proliferation of lung progenitor cells (EpCAM(neg)/Sca-1(high) lung mesenchymal stromal cells – LMSCs, EpCAM(pos)/Sca-1(low) epithelial progenitor cells, proSP-C(pos) alveolar type II epithelial cells – AECII, and CD31(pos) – endothelial cells) was tracked to day 3 or 7 after pneumonectomy (PNX) or SHAM surgery in 3, 9, and 17 month mice.
Read more at PubMed: http://www.ncbi.nlm.nih.gov/pubmed/23895415

Cell therapy for lung diseases. Report from an NIH-NHLBI workshop, November 13-14, 2012.

Michael A. Matthay, Piero Anversa, Jahar Bhattacharya, Bruce K. Burnett, Harold A. Chapman, Joshua M. Hare, Derek J. Hei, Andrew M. Hoffman, Stella Kourembanas, David H. McKenna, Luis A. Ortiz, Harald Ott, William Tente, Bernard Thébaud, Bruce C. Trapnell, Daniel J. Weiss, Jason X.-J. Yuan, Carol J. Blaisdell.  Cell Therapy for Lung Disease.  Report from an NIH-NHLBI Workshop November 13-14 2012. Am J Resp Crit Care Med.  2013, 1;188(3):370-5. PMID 23713908.

The National Heart, Lung, and Blood Institute (NHLBI) of the National Institutes of Health convened the Cell Therapy for Lung Disease Working Group on November 13-14, 2012, to review and formulate recommendations for future research directions. The workshop brought together investigators studying basic mechanisms and the roles of cell therapy in preclinical models of lung injury and pulmonary vascular disease, […]

Endogenous distal airway progenitor cells, lung mechanics, and disproportionate lobar growth following long-term postpneumonectomy in mice.

Eisenhauer P, Earle B, Loi R, Sueblinvong V, Goodwin M, Allen G, Lundblad L, Mazan M, Hoffman AM,  Weiss DJ.  Endogenous Distal Airway Progenitor Cells, Lung Mechanics, and Disproportionate Lobar Growth following Long-Term Post-Pneumonectomy in Mice.  Stem Cells, 2013, 1;188(3):370-5; PMID: 23533195

Using a model of postpneumonectomy (PNY) compensatory lung growth in mice, we previously observed an increase in numbers of a putative endogenous distal airway progenitor cell population (CCSP(pos) /pro-SPC(pos) cells located at bronchoalveolar duct junctions [BADJs]), at 3, 7, and 14 days after pneumonectomy, returning to baseline at 28 days post-PNY. As the origin of these cells is poorly understood, we evaluated whether bone marrow cells contributed to the pool of these or other cells during prolonged post-PNY lung regrowth.
Read more at PubMed: http://www.ncbi.nlm.nih.gov/pubmed/23533195

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