Dr. Thane is a Post-Doctoral Scholar supported by an NIH funded project (HL112987-01A1) in our lab. She is investigating the safety and efficacy of autologous lung-derived mesenchymal stromal/stem cell (LMSCs) therapy for emphysema, employing both a sheep model of emphysema and ex vivo model of LMSCs-scaffold interactions to evaluate biological influence of scaffolds (e.g. fibrin) on paracrine signaling. She is also a clinician in the Hospital for Large Animals at Cummings School.
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Dr. Kristen Thane is investigating the effects of biomimetic scaffolds on paracrine signaling of lung derived mesenchymal stem cells (LMSCs). Shown are LMSCs seeded into a fibrin scaffold for 24 hr at low (left) and high (right) power, showing cell spreading and formation of nanotubes that join the cells.
